NEW YORK, USA: 1Day Sooner is proud to receive a $2 million grant from Open Philanthropy to fund our work accelerating development of vaccines for neglected diseases by advocating on behalf of challenge volunteers. The grant proposal includes a cost-benefit analysis and a list of potential projects.
These unrestricted funds are meant to cover a third of our intended budget over the next two years. 1Day Sooner intends to focus on accelerating development of vaccines for neglected diseases like Group A Strep, tuberculosis, and shigella through the use of challenge studies and innovative regulatory and financial structures like advance market commitments. 1Day Sooner aims to save a million lives through accelerated vaccine development before the year 2040.
Challenge trials are not used often enough. The ethical considerations must be carefully weighed, but the moral imperative to save lives in the developing world is rarely given full weight by bioethicists in wealthy countries. Even in the case of the COVID pandemic, where challenge trials were used, only one country ran challenge trials and has not treated those trials with urgency or transparency. This grant will help us unlock the promise of challenge trials.
Our current work includes:
1Day Sooner represents the voice of challenge volunteers who participate in medical research out of a desire to save lives and expand the frontiers of science. In the long term, we hope empowering these research participants will improve research transparency and exercise a pro-social gravitational pull on pharma decision-making.
“We are glad 1Day Sooner helped give challenge volunteers a voice in the development of vaccines against COVID-19. We hope this funding helps bring about challenge trials that speed up the development of vaccines against other infectious diseases that afflict millions of people worldwide, especially people in low- and lower-middle-income countries.”—Jacob Trefethen, Program Officer, Open Philanthropy
“We are honored to receive this grant and excited for the projects it will enable us to pursue. The potential of challenge trials in vaccine development has yet to be fully realized. Challenge volunteers will help save lives.”—Gavriel Kleinwaks, Communications Lead, 1Day Sooner
“Having experienced firsthand the battle between the great benefits of challenge studies and the crippling effects of slowness and uncertainty, I wholeheartedly thank Open Philanthropy. I hope this grant will allow 1Day Sooner to continue to advocate for challenge studies both in pandemic and non-pandemic situations, reducing barriers in these lifesaving studies.”—Alastair Fraser-Urquhart, UK Chapter Manager, 1Day Sooner; Imperial College London challenge trial participant
“Human challenge studies could help move vaccine development in the right direction.”—Stanley Plotkin, Emeritus Professor of Pediatrics, Perelman School of Medicine, University of Pennsylvania
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